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Dharma Bioscience has a unique team comprised of professionals with extensive experience in the scientific, medical, and clinical research fields, leading Regenerative Medicine treatments in Latin America.

Contact Info 1 de Mayo 840. Rosario. Santa Fe. Argentina. +54 341 254 5814 info@dharmabioscience.com
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    CHALLENGE

    Osteoarthritis (OA) is a long-term chronic disease characterized by the deterioration of cartilage in joints which results in bones rubbing together and creating stiffness, pain and impaired movement. The disease most commonly affects the joints in the knees, hands and hips.

    Approximately 500 million people suffer from osteoarthritis worldwide, and by 2040, it will affect 1.9 billion people.

    As the leading cause of permanent disability, osteoarthritis still has no cure.

    Considered a serious disease, OA affects mobility, increases the risk of heart disease, can lead to depression and severely affect people’s quality of life.

    The Solution

    Modified miRNAs

    Unleashing the potential of microRNAs, we are stimulating cartilage regeneration by modulating the cellular microenvironment within the joints.

    Thanks to a unique molecule containing a specific combination of these molecules, we are able to modify the cellular environment in the joints.

    How does it work?
    MicroRNAs are small molecules that regulate gene expression.
    Our aim is to restore the balance of differentiation of resident cells into cartilage.

    Rather than genetically modifying cells, we are activating signaling networks that are interconnected and complementary.

    High stability

    Modfield miRNAs stand out for their exceptional stability, ensuring long-lasting and consistent therapeutic effects. This high stability translates to sustained cartilage regeneration, offering a reliable solution in joint health.

    Auto-catalytic

    Our technology is self-enhancing, featuring an auto-catalytic mechanism. This means that once initiated, the miRNAs continue to propagate their healing effects, amplifying their impact on joint regeneration without additional interventions.

    Highly-silencing

    With a highly-silencing capability, Modfield miRNAs precisely target and regulate key genes involved in cartilage repair. This selective silencing is crucial for directing the cellular activities towards effective joint restoration.

    Lower OFF target

    Our miRNAs are meticulously designed to minimize off-target effects, ensuring that the therapeutic action is concentrated precisely where it's needed. This precision not only enhances effectiveness but also significantly reduces potential side effects, making it a safer choice for joint health.

    Technology

    We propose a groundbreaking and novel approach to the treatment of osteoarthritis based on small RNAs to promote or inhibit the expression of endogenous genes, thereby modulating the biology of joint-resident mesenchymal stem cells (MSCs).Our research is aimed at identifying the best combination of miRNAs for injection into the degenerative areas to induce stable cell differentiation and promote tissue repair.

    Our Journey

    Precision diagnosis

    Utilizing advanced miRNA diagnostics, we precisely identify the specific needs of each patient's knee osteoarthritis, setting the stage for a targeted treatment approach.

    Poli-miRs formulation

    Our unique poli-miRs formulation encapsulates specific miRNAs within nanoparticles, creating an autocatalytic RNA molecule that effectively targets degenerative areas.

    Cellular Restoration

    This stage involves the strategic use of miRNA combinations to stimulate the resident mesenchymal stem cells (MSC) in joints, fostering cellular repair and restoration.

    Tissue Regeneration

    The culmination of our approach is seen in the targeted tissue regeneration, where the optimized miRNA mix promotes stable cell differentiation and tissue repair, offering a new horizon in osteoarthritis treatment.

    Advantages

    miRNA therapy can target particular genes contributing to osteoarthritis onset and progression. This approach enables our solution to selectively address the identified genes, potentially enhancing the efficacy of the treatment for the disease.

    With our innovative technology and products, we can decrease the number of joint replacement surgeries by half. This will result in a significant reduction in healthcare costs and enhance the quality of life for millions of people worldwide.

    This technology has the potential to offer a cost-effective therapeutic alternative to stem cell therapy. Unlike stem cell therapy, which demands the isolation and culture of cells, miRNA therapy can be synthesized chemically in large quantities, significantly reducing treatment costs.

    Our Team

    Founders

    Dharma Bioscience has a unique team comprised of professionals with extensive experience in the scientific, medical, and clinical research fields, leading Regenerative Medicine treatments in Latin America.

    Gastón Topol, M.D
    Co-Founder, CEO

    ✔ 22 years working to improve Osteoarthiris.
    ✔ >30.000 Intra-articular procedures experience.
    ✔ OMS Latam leader in orthopedic medicine.
    ✔ Advisor in sport medicine at the Texas University, Austin.

    Franco Cescotti, P.T
    Co-Founder, COO

    ✔ 15 years experience in Regenerative Rehabilitation.
    ✔ IAE Business School.
    ✔ Master University of Salamanca.

    Diego Croci, Ph.D
    Co-Founder, CSO

    ✔ 16 years of experience Science.
    ✔ >60 scientific papers.
    ✔ Profesor at Cuyo University and invited Professor Cretel-Paris Est University.
    ✔ Awarded as best Talent young Scientist in Latam.

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